Differential vascular growth in postpneumonectomy compensatory lung growth
نویسندگان
چکیده
منابع مشابه
Hepatocyte growth factor stimulates proliferation of respiratory epithelial cells during postpneumonectomy compensatory lung growth in mice.
Although it is known that the lung undergoes compensatory growth after pulmonary resection, mechanisms by which lung cells exhibit compensatory proliferation are not well defined. We investigated the involvement of hepatocyte growth factor (HGF) in postpneumonectomy compensatory lung regeneration in mice, because HGF has mitogenic and morphogenic actions on lung epithelial cells. Following left...
متن کاملHIGHLIGHTED TOPIC Lung Growth and Repair Vascular growth and remodeling in compensatory lung growth following right lobectomy
Le Cras, Timothy D., Lucas G. Fernandez, Patricia A. Pastura, and Victor E. Laubach. Vascular growth and remodeling in compensatory lung growth following right lobectomy. J Appl Physiol 98: 1140–1148, 2005. First published October 29, 2004; doi:10.1152/ japplphysiol.00479.2004.—Studies in animal models have shown that, following lobectomy (LBX), there is compensatory growth in the remaining lun...
متن کاملCompensatory Lung Growth After Pneumonectomy
Pneumonectomy, the surgical removal of a lung, elicits a number of anatomical changes within the thoracic cavity that augments the diffusion capacity of the remaining lung. Pneumonectomy directs the entire cardiac output into the remaining lung and creates an empty hemithorax that results in a shift of the mediastinum toward the vacated thoracic compartment. In a number of experimental animal m...
متن کاملVascular growth and remodeling in compensatory lung growth following right lobectomy.
Studies in animal models have shown that, following lobectomy (LBX), there is compensatory growth in the remaining lung. The vascular growth response following right LBX (R-LBX) is poorly understood. To test the hypothesis that arterial growth and remodeling occur in response to LBX, in proportion to the amount of right lung tissue removed, two (24% of lung mass; R-LBX2 group) or three right lo...
متن کاملEffect of unilateral diaphragmatic paralysis on postpneumonectomy lung growth.
Respiratory muscle-associated stretch has been implicated in normal lung development (fetal breathing movements) and postpneumonectomy lung growth. To test the hypothesis that mechanical stretch from diaphragmatic contraction contributes to lung growth, we performed left phrenic nerve transections (PNT) in mice with and without ipsilateral pneumonectomy. PNT was demonstrated by asymmetric costa...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2007
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2006.09.003